Exploring Polynucleotides (Salmon DNA) injections for Skin and Hair Rejuvenation: Effective Skin Treatment for Every Patient
- Dr Vahe
- Sep 7
- 5 min read
Updated: Sep 29
Introduction
In recent years, the aesthetics industry has witnessed a remarkable surge in interest towards regenerative injectables. Among the most innovative treatments available today are polynucleotides (PNs), sometimes referred to as salmon DNA injectables. These bioactive molecules have become a cornerstone in skin and hair restoration thanks to their ability to repair, hydrate, and stimulate cellular regeneration.
Unlike conventional fillers that focus primarily on volume, or skin boosters that offer short-term hydration, polynucleotides go deeper. They improve the biological foundation of skin and scalp health, making them a versatile and effective solution for patients of all ages and skin types.
In this article, we explore what polynucleotides are, how they work, their applications for skin and hair rejuvenation, the different brands available, and why they are quickly becoming a treatment of choice in aesthetic medicine.
What Are Polynucleotides?
Polynucleotides are fragments of DNA molecules, often derived from salmon or trout sperm, due to their remarkable biocompatibility with human tissues. When injected into the skin or scalp, these DNA chains act as:
Scavengers of free radicals – reducing oxidative stress that accelerates ageing.
Tissue regenerators – stimulating fibroblast activity to promote collagen and elastin production.
Hydration boosters – binding water molecules to restore skin elasticity and plumpness.
Cell stimulators – supporting natural tissue repair and renewal.
Their regenerative properties make them suitable for a broad range of patients, whether seeking anti-ageing, scar improvement, or solutions for thinning hair.
The Science Behind Polynucleotides for Skin treatments
Polynucleotides known also as Salmon DNA work by enhancing the extracellular matrix (ECM) – the supportive network of proteins and molecules that keep skin firm, hydrated, and resilient.
Antioxidant effect: They neutralise harmful reactive oxygen species (ROS), slowing down skin ageing caused by UV damage, pollution, and stress.
Cell regeneration: They activate fibroblasts (collagen-producing cells), improving skin texture, density, and elasticity.
Angiogenesis: They promote new blood vessel formation, improving oxygenation and nutrient delivery to treated areas.
Wound healing: Polynucleotides accelerate repair mechanisms, which is why they are also used in post-surgical recovery and scar management.
In the scalp, PNs create a healthier environment for hair follicles, improving density, thickness, and overall vitality of hair growth.
Benefits of Polynucleotides (Salmon DNA) injections in Aesthetic Medicine
1. Skin Rejuvenation
Reduction of fine lines and wrinkles
Improved skin elasticity and hydration
Treatment of acne scars and surgical scars
Softer and smoother skin texture
Long-term regenerative results rather than quick fixes
2. Under-Eye Rejuvenation
Polynucleotides are especially effective for the delicate under-eye area, where traditional fillers can sometimes look heavy. They reduce:
Dark circles
Crepiness
Hollowing and fine lines
3. Hair Regeneration
When injected into the scalp, polynucleotides:
Stimulate dormant hair follicles
Increase blood circulation and scalp health
Improve hair density and thickness
Provide an effective, natural-looking option for men and women suffering from thinning hair
4. Combination Therapy
Polynucleotides are safe to combine with other treatments, such as:
Dermal fillers
PRP (Platelet-Rich Plasma)
Laser resurfacing
Microneedling
This makes them a flexible tool in comprehensive rejuvenation plans.
Popular Brands of Polynucleotides
Several medical-grade PN products are now available, each designed for specific applications:
Rejuran – ideal for face, neck, and décolletage rejuvenation.
Plinest – excellent for anti-ageing and scar reduction.
Ameela – highly popular for under-eye treatments.
Lumi Eyes – specialised for periocular rejuvenation.
Amy Eyes – an alternative for delicate under-eye areas.
Pure Eyes – focuses on improving dark circles and skin tone.
Aurora - ideal for face, neck, and décolletage rejuvenation, most potent mix with Hyaluronic acid, gluthatione, growth Factor and Peptides.
Each brand has slightly different molecular weights and formulations, making them suitable for tailored treatments depending on the patient’s needs.
Treatment Protocols of Polynucleotides (Salmon DNA) injections for skin and hair at Dr Vahe Clinic
Typically, a course of 3–4 sessions is recommended, spaced 2–4 weeks apart. Maintenance treatments can be performed every 6–12 months depending on individual goals.
For Skin:
2–4 sessions initially
Maintenance: once every 6–12 months
For Hair:
3–6 sessions initially
Maintenance: every 6 months
Safety Profile
Polynucleotides are remarkably safe, with a low risk of adverse reactions. Since they are highly purified, the chance of allergic responses is minimal. The most common side effects are temporary redness, swelling, or mild bruising at the injection site.
Who Is a Suitable Candidate?
Polynucleotides can benefit:
Patients in their 20s and 30s looking to prevent early ageing.
Individuals in their 40s–60s seeking skin regeneration and wrinkle reduction.
Both men and women with thinning hair or early hair loss.
Patients with acne scarring, surgical scars, or sun-damaged skin.
Because of their natural regenerative mechanism, polynucleotides are a universal solution, adaptable to nearly every skin type and concern.
Comparing Polynucleotides with Other Injectables
Treatment | Mechanism | Best For | Longevity |
Dermal Fillers | Volume replacement | Cheeks, lips, chin | 9–18 months |
Skin Boosters | Hydration | Fine lines, glow | 6 months |
PRP | Growth factors | Hair, skin healing | Variable |
Polynucleotides | Cellular regeneration | Skin & hair | Long-lasting regenerative effects |
This table highlights how PNs stand out as a biological rejuvenator rather than a purely aesthetic filler.
Case Studies & Clinical Evidence
Several clinical trials have demonstrated the effectiveness of polynucleotides:
Skin Quality Improvement: Studies show enhanced skin thickness, hydration, and elasticity within 2–3 months of treatment.
Hair Growth: Clinical data supports increased follicle density in patients with androgenic alopecia.
Scar Treatment: PNs have shown promising results in post-acne and post-surgical scar remodelling.
Patient Experience
Most treatments are quick, well-tolerated, and minimally invasive. Topical anaesthetic cream is often used, and patients can return to normal activities shortly after.
Results are progressive rather than immediate, with the best outcomes visible after the full course of treatments. Patients typically notice:
Fresher, more radiant skin
Reduced fine lines and wrinkles
Healthier scalp and hair regrowth
Why Choose Polynucleotides?
Polynucleotides represent a new generation of regenerative injectables that go beyond simply restoring lost volume. They target the root causes of ageing and hair thinning by repairing, regenerating, and protecting tissues from within.
For patients seeking natural, long-term improvements in both skin and hair health, polynucleotides offer a solution that is effective, versatile, and safe.
Conclusion
As the demand for regenerative treatments continues to grow, polynucleotide injectables are emerging as a cornerstone of modern aesthetic medicine. With their ability to rejuvenate skin, restore hair, and improve tissue health at a cellular level, they are an invaluable tool for practitioners and a life-changing option for patients.
Whether addressing fine lines, scars, under-eye concerns, or thinning hair, polynucleotides provide effective solutions for every patient.
Ready to experience natural skin and hair regeneration? At Dr Vahe Clinic, we offer the latest polynucleotide (salmon DNA) injectable treatments tailored to your individual needs. Book your consultation today and discover a regenerative solution designed for long-lasting skin and hair rejuvenation.
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